Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors

Dopamine- induced hypophagia is mediated via NMDA and mGlu1 receptors in chicken

Background: Feeding behavior is regulated by a complex network which interacts via diverse signals from central and peripheral tissues. It is known dopaminergic and glutamatergic systems have crucial role on food intake regulation but scarce reports exist on their interaction in appetite regulation in broilers. OBJECTIVES: The present study was designed to examine the role of glutamatergic syst...

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.

We have shown previously that low doses of selective sigma (sigma)-receptor ligands potentiate the excitatory response of pyramidal neurons to NMDA in the CA3 region of the dorsal hippocampus in the rat. Because progesterone competitively displaces the binding of the ligand N-[3H]allyl-normetazocine (SKF-10,047), the present studies were undertaken to determine in vivo the effect of neuroactive...

Sigma, PCP, and NMDA Receptors, 133

Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors.

Cocaine-induced plasticity of glutamatergic synaptic transmission in the ventral tegmental area (VTA) plays an important role in brain adaptations that promote addictive behaviors. However, the mechanisms responsible for triggering these synaptic changes are unknown. Here, we examined the effects of acute cocaine application on glutamatergic synaptic transmission in rat midbrain slices. Cocaine...

RAPID COMMUNICATION NMDA Receptor-Mediated Oscillatory Activity in the Neonatal Rat Spinal Cord Is Serotonin Dependent

MacLean, Jason N., Kristine C. Cowley, and Brian J. Schmidt. spinal cats reverses perturbations of the locomotor pattern NMDA receptor-mediated oscillatory activity in the neonatal rat produced by 5-HT agonists (Barbeau and Rossignol 1990), spinal cord is serotonin dependent. J. Neurophysiol. 79: 2804– it remains to be shown whether endogenous 5-HT receptor 2808, 1998. The effect of serotonin (...